Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We found CDC14A and MTMR3 mutations in five and one cancer (s), respectively.
|
20477815 |
2010 |
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We found CDC14A and MTMR3 mutations in five and one cancer (s), respectively.
|
20477815 |
2010 |
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We also identified a molecular signature for the presence of immunoglobulin variable heavy chain somatic mutation, which includes a number of genes potentially relevant in cancer (CDC14A, ras, and others).
|
14678979 |
2003 |
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We also identified a molecular signature for the presence of immunoglobulin variable heavy chain somatic mutation, which includes a number of genes potentially relevant in cancer (CDC14A, ras, and others).
|
14678979 |
2003 |
Dental caries
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two families with recessive ESRRB mutations and DFNB35 hearing impairment showed more extensive dental destruction by caries.
|
25023176 |
2014 |
Caries (morphologic abnormality)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two families with recessive ESRRB mutations and DFNB35 hearing impairment showed more extensive dental destruction by caries.
|
25023176 |
2014 |
hearing impairment
|
0.110 |
GeneticVariation
|
phenotype |
BEFREE |
Two families with recessive ESRRB mutations and DFNB35 hearing impairment showed more extensive dental destruction by caries.
|
25023176 |
2014 |
Colorectal Carcinoma
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
The CDC14A and MTMR3 mutations detected in the GC and CRC were deletion or duplication mutations of one base in the nucleotide repeats that would result in premature stops of the amino acid syntheses.
|
20477815 |
2010 |
Malignant neoplasm of stomach
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The CDC14A and MTMR3 mutations detected in the GC and CRC were deletion or duplication mutations of one base in the nucleotide repeats that would result in premature stops of the amino acid syntheses.
|
20477815 |
2010 |
Mycoses
|
0.010 |
Biomarker
|
group |
BEFREE |
Taken together, these results not only reveal the importance of the CDC14 phosphatase in the regulation of development, aflatoxin biosynthesis and virulence in <i>A. flavus</i>, but may also provide a potential target for controlling crop infections of this fungal pathogen.
|
29868497 |
2018 |
Nonsyndromic Deafness
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Mutations of ESRRB encoding estrogen-related receptor beta cause autosomal-recessive nonsyndromic hearing impairment DFNB35.
|
18179891 |
2008 |
DEAFNESS, AUTOSOMAL RECESSIVE 32
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness.
|
27259055 |
2016 |
DEAFNESS, AUTOSOMAL RECESSIVE 32
|
0.700 |
Biomarker
|
disease |
CTD_human |
Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness.
|
27259055 |
2016 |
DEAFNESS, AUTOSOMAL RECESSIVE 32
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness.
|
27259055 |
2016 |
DEAFNESS, AUTOSOMAL RECESSIVE 32
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness.
|
27259055 |
2016 |
Nonsyndromic Deafness
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Mapping of a new autosomal recessive nonsyndromic hearing loss locus (DFNB32) to chromosome 1p13.3-22.1.
|
12634867 |
2003 |
Nodular Sclerosis Classical Hodgkin Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Linkage analysis indicates that in this family the NSHL locus, (DFNB35) maps to a 17.54 cM region on chromosome 14 flanked by markers D14S57 and D14S59.
|
12529709 |
2003 |
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Breast Carcinoma
|
0.110 |
Biomarker
|
disease |
BEFREE |
In gene-level analyses, CDC25C, SCC1/RAD21, TLK2, and SMC6L1 were associated (P < 0.05) with overall breast cancer risk, CDC6, CDC27, SUMO3, RASSF1, KIF2, and CDC14A were associated with high grade breast cancer risk, and EIF3S10 and CDC25A were associated with both.
|
21607584 |
2011 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
In gene-level analyses, CDC25C, SCC1/RAD21, TLK2, and SMC6L1 were associated (P < 0.05) with overall breast cancer risk, CDC6, CDC27, SUMO3, RASSF1, KIF2, and CDC14A were associated with high grade breast cancer risk, and EIF3S10 and CDC25A were associated with both.
|
21607584 |
2011 |
DEAFNESS, AUTOSOMAL RECESSIVE 32
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
CDC14A phosphatase is essential for hearing and male fertility in mouse and human.
|
29293958 |
2018 |
DEAFNESS, AUTOSOMAL RECESSIVE 32
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
CDC14A phosphatase is essential for hearing and male fertility in mouse and human.
|
29293958 |
2018 |
DEAFNESS, AUTOSOMAL RECESSIVE 32
|
0.700 |
Biomarker
|
disease |
CTD_human |
CDC14A phosphatase is essential for hearing and male fertility in mouse and human.
|
29293958 |
2018 |
DEAFNESS, AUTOSOMAL RECESSIVE 32
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
CDC14A phosphatase is essential for hearing and male fertility in mouse and human.
|
29293958 |
2018 |
Nonsyndromic Deafness
|
0.320 |
Biomarker
|
disease |
CLINGEN |
CDC14A phosphatase is essential for hearing and male fertility in mouse and human.
|
29293958 |
2018 |